There are many ways to treat pain so that you can enjoy a better quality of life. Learning your options can help keep you safe while still allowing you to do what matters to you.

Start by talking to your doctor about ways to manage your pain  that don’t involve prescription opioids,  says the Centers for Disease Control and Prevention.

There are other treatments that may work other than opioids. And they might not have the risks and side effects that come with strong medicines like opioids.

Examples of prescription opioids include hydrocodone, oxycodone and fentanyl. Fentanyl and other man-made opioids are the most common drugs involved in overdose deaths, says the National Institute on Drug Abuse. 

Fentanyl is 50 to 100 times stronger than morphine. It works on parts of the brain that control pain and emotions. It can produce feelings of happiness, but also confusion, dangerous breathing problems and blackouts. Fentanyl’s high strength significantly raises the chances of overdose because people can easily underestimate the dose they’re taking.

The illegal forms of fentanyl are sold as a powder or made into pills that look like real prescription opioids. It Fentanyl is also often mixed with other drugs without people knowing. This hidden mixture makes it very dangerous.

If you think someone has overdosed, call 911 so they can get urgent medical attention. Medical workers may be able to give naloxone to reverse a fentanyl overdose. If you or a family member are currently taking opioids, you may want to talk to your health care provider about keeping naloxone in your home and learning how to use it safely. 

Safer Options

While prescription opioids may work for some types of pain, other medicines and non-drug treatments can also help control pain. Some of these options may be covered by health insurance, depending on your plan. To find out what benefits are covered, log into your member account and go to Coverage.

• Taking acetaminophen or ibuprofen
• Exercising and losing weight
• Using cognitive behavioral therapy to learn how to alter the physical, behavioral and emotional triggers of pain
• Starting exercise therapy
• Using targeted injections

Alternatives to Medicine
You may want to explore other types of treatments that don’t involve medicine. There are many alternative treatments that may help, such as:

• Yoga
• Meditation
• Chiropractic care
• Physical therapy
• Massage therapy
• Acupuncture
• Spinal cord stimulation, radiofrequency ablation or electrical nerve stimulation

Medicine Safety: You Play an Important Role

If you are considering opioids, there is a risk of misuse.  It’s vital to know your role in medicine safety:

• Work with your doctor to make a plan to manage your pain. Having one main doctor to coordinate and manage all of your care helps.
• Consider ways to manage your pain that do not involve opioids.
• Talk to your doctor about all medicine side effects, potential negative interactions and other concerns.
• Follow up with your doctor regularly.
• Be aware of the effects that opioids have on your body. 

Always Follow Directions

• Never take prescription opioids in greater amounts or more often than prescribed.
• Don’t take opioids with alcohol and other substances or medications. It is not safe to mix opioids with other drugs. Even some over-the-counter medicines can be dangerous if taken while you’re taking opioids.
• Do not share or sell your prescription opioids.
• Store prescriptions in a safe place. Make sure they are out of reach of others, such as children and guests.
• Get rid of unused medicines the right way. The U.S. Food and Drug Administration offers detailed information on how to safely dispose of medicine. 

Talk to your doctor or health care professional about any health questions or concerns.

The above material is for informational purposes only and is not a substitute for the independent medical judgment of a physician or other health care provider.

Sources: Working Together With Your Doctor to Manage Your Pain,  Centers for Disease Control and Prevention, 2024; Nonopioid Therapies,  CDC, 2024; About Prescription Opioids,  CDC, 2025; Preventing Opioid Misuse,  CDC, 2024; Safe Disposal of Medicines,  Food and Drug Administration, 2024; Prescription Opioids and Heroin,  University of Missouri-Kansas City; Lifesaving Naloxone,  CDC, 2023; New sources: Fentanyl,  National Institute on Drug Abuse, 2025; Non-Drug Pain Management,  National Library of Medicine, 2025; Nonopioid Therapies for Pain Management,  CDC, 2025; An update on non-pharmacological interventions for pain relief,  National Library of Medicine, 2025