GLP-1s for Weight Loss

GLP-1s are a class of drugs commonly used to treat Type 2 diabetes. But some GLP-1s are also FDA approved for treating obesity and obesity-related conditions.

Here’s what you need to know.

What are GLP-1s?
GLP-1 is a hormone that helps control blood sugar and increase insulin production. While your body naturally produces GLP-1, how much is made can slow because of things like chronic stress, poor gut health and hormone changes.

GLP-1 drugs, or GLP-1s, can help cause the same responses in the body when the body’s hormone isn’t working as well as it should.

How do GLP-1s work for weight loss?
GLP-1s also slow down how quickly food digests and leaves your stomach, so you feel full faster and longer after eating.

Combined, this can help you lose weight.

And make sure to combine your prescription with healthy lifestyle changes like diet and exercise. Using GLP-1s alone won’t give you lasting results.

What are the benefits of using GLP-1s for weight loss?
Along with diet and exercise, GLP-1s help with weight loss by curbing your appetite. They make you feel full faster so that you eat less.

Which GLP-1s are FDA approved for weight loss?
Several types of GLP-1s are approved for weight loss and other conditions besides diabetes. The brand names to look for are Wegovy® (semaglutide), Saxenda (liraglutide) and Zepbound® (tirzepatide). FDA approval means doctors can prescribe them for weight loss.

What are the risks and side effects of GLP-1s?
The most reported side effects are nausea, diarrhea and stomach pain, and reactions at the injection site.

Some underlying health issues can put you at risk of worse side effects, like gallbladder problems or swelling of the pancreas.

Are GLP-1s through online sources safe?
It’s important to use GLP-1s only under the care of a doctor you know and trust.

There are many products being sold online that may not be approved by the FDA. Drugs that are not FDA-approved may not be as safe or effective. Check the FDA website for concerns  about using these drugs that could put your health at risk. 

Does insurance cover GLP-1s for weight loss?
Most plans don’t cover GLP-1s for weight loss. However, doctors can prescribe GLP-1s without it being a covered benefit. This means you will pay out-of-pocket for the prescription.

Check your plan benefits. If part of your benefits, you likely will need approval from your health plan before you start treatment. Be sure to talk to your doctor about your options. Work together to decide what is best for you.

Source: Diabetes drugs and weight loss,  Mayo Clinic, 2025; GLP-1 Agonists,  Cleveland Clinic, 2023; FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss,  U.S. Food and Drug Administration, 2025